Wednesday, August 27, 2014

EDS Article About How The Body With EDS Does It's Thing.

Knowing that it is EDS helps, but it still doesn't answer all the questions, but I guess that is not so uncommon in life.  

Knowing anything about Ehlers Danlos helps me feel better about what is going on in my body and what is making life so hard at times and even though just knowing might not fix anything, it does give me a peace of mind somehow. 

I think others might feel the same as I do so I want to share an article that I found about EDS that was surprising to me. I love to learn new things and stuff and I am glad to find this article because now I have more info to research. I love to do research!!! 

I haven't researched much about the info in the article yet, but it is interesting and it will give me something to do for a while and then I will post my findings to share with you. 

The way that I found this article is by researching trying to find which proteins were not used in people with EDS and this popped up...... 
So here is the article:

Lysyl oxidase: properties, regulation and multiple functions in biology.


Lysyl oxidase (LO) is a copper-dependent amine oxidase that plays a critical role in the biogenesis of connective tissue matrices by crosslinking the extracellular matrix proteins, collagen and elastin. Levels of LO increase in many fibrotic diseases, while expression of the enzyme is decreased in certain diseases involving impaired copper metabolism. While the three-dimensional structure of the enzyme is not yet available, many of its physical-chemical properties, its novel carbonyl cofactor, and its catalytic mechanism have been described. Lysyl oxidase is synthesized as a preproprotein, secreted as a 50 kDa, N-glycosylated proenzyme and then proteolytically cleaved to the 32 kDa, catalytically active, mature enzyme. Within the past decade, the gene encoding LO has been cloned, facilitating investigations of the regulation of expression of the enzyme in response to diverse stimuli and in numerous disease states. Transforming growth factor-beta, platelet-derived growth factor, angiotensin II, retinoic acid, fibroblast growth factor, altered serum conditions, and shear stress are among the effectors or conditions that regulate LO expression. New, LO-like genes have also been identified and cloned, suggesting the existence of a multigene family. It has also become increasingly evident that LO may have other important biological functions in addition to its role in the crosslinking of elastin and collagen in the extracellular matrix.
PMID: 9524359 [PubMed - indexed for MEDLINE]        

Hopefully, this will peak your interest and if you do research be sure and share it with the rest of us so we can maybe learn more about why our bodies are sooooo.... well, the way they are.